By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play an important function in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium delivery throughout those membranes is a two-step procedure: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated by means of a number of diversified hormones. The sodium channels additionally play an important position in a couple of illness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful range presents the 1st in-depth trade of rules bearing on those sodium channels, their legislation and involvement in general and pathophysiological occasions. Key beneficial properties * Summarizes present country of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal law of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * offers principles on sodium channels and ailment
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Additional info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
Functional degenerin-containing chimeras identify residues essential for arniloride-sensitive Na+ channel function. J. Biol. Chem. 270,11735-1 1737. , and Lazdunski, M. (1995b). Molecular cloning and functional expression of a novel amiloride-sensitive Na’ channel. J. B i d . Chem. 270,27411-27414. , and Handler, J. S . (1986). Activators of protein kinase C inhibit sodium transport in A6 epithelia. Am. J. Physiol. 250, C517-C522. Zagotta, W. , and Aldrich, R. W. (1990). Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB.
270,27411-27414. , and Handler, J. S . (1986). Activators of protein kinase C inhibit sodium transport in A6 epithelia. Am. J. Physiol. 250, C517-C522. Zagotta, W. , and Aldrich, R. W. (1990). Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250, 568-571. CHAPTER 2 Membrane Topology,Subunit Composition, and Stoichiometry of the Epithelial NaS Channel Peter M. Snyder,” Chun Cheng,? and Michael J. Welsh? Departments of Internal Medicine and Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242 I.
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