By Dr. G. M. Kostner (auth.), Dr. Maryvonne Rosseneu, Prof. Dr. Kurt Widhalm, Dr. Jochen Jarausch (eds.)
There is expanding facts for the clinicial price of the apo lipoprotein measurements. in addition to ldl cholesterol in plasma and li poprotein fractions, that's at the moment used as a hallmark of cardiovascular chance, the dimension of the AI and B apolipopro teins gives you additional info concerning the sufferers' scientific prestige. numerous stories exhibit that apo B is greater and apo AI is reduce in sufferers with angiographically documented heart dis ease than in symptomatic sufferers with out heart sickness. in addition, discriminant research indicated that the focus of Apo AI and B in plasma are larger discriminators than lipo protein ldl cholesterol for making a choice on sufferers with heart disorder. In a few stories the apo Bjapo AI ratio seems to be a extra strong predictor than person lipoproteins. In a up to date research performed in males, apolipoproteins AI and B have been higher correlated with the severity of heart problems than HDL and cholesterol. The predictive energy of apolipoproteins may perhaps even though now not be established in all stories and the price of apolipoprotein measurements within the box of medical chemistry continues to be debatable. this can be most likely because of discrepancies among the result of quite a few reports, bobbing up from variations within the form of immunoassays, the shortcoming of common reference fabrics, vary ences among examine protocols, diversifications within the number of sufferers and within the grading and interpretation of coronary lesions.
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Additional resources for Apolipoproteins in Lipid Disorders: Risk Assessment and Monitoring
150 0 C. to to o =N I lIa lib III IV V~ 0 N I o g. e0 g. 1000 N I lIa lib III IV V 200 100 N I lIa lib Fig. 2. Plasma concentrations of apolipoproteins AI, All, Band E in primary dyslipidemias classified according to Fredrickson. Solid bars = mean values; open bars = + SD range 22 M. Rosseneu while the apo All concentrations change only in type IV dyslipidemia. Hypolipoproteinemias A betalipoproteinemia This primary form of hypolipoproteinemia is characterized by the absence of apo B 100 in plasma .
Different studies have compared the levels of apolipoproteins in relatives of persons with CHD [9, 13, 22]. Almost all studies show a stronger association of parental history of CHD with apolipoprotein levels than with lipid or lipoprotein cholesterol. Apo Band apo AI levels are equally important. Kukita et al. [22J were one ofthe first to report that apo AI and apo B levels better distinguished relatives of CHD patients from controls than did HDL-C, TC and TG. After univariate analysis between CHD patients and controls, apo B was the best discriminator followed by HDL-C in men, while in women, apo AI was the best discriminator [23J.
14. 15. 16. 17. 18. 19. 20. 25 hypothyroidism before and during treatment. Eur J Clin Invest 14: 12-15 Riesen WF, Mordasini R, Salzmann C, Theler A, Ourtner HP (1980) Apolipoproteins and lipids as discriminators of severity of coronary heart disease. Atherosclerosis 37: 157-162 Rosseneu M, Bury J (1988) Apolipoprotein assays for the diagnosis of hyperlipidemias. Impact on Prevention of Atherosclerotic Diseases: 143-154 Rosseneu M, De Backer G, Caster H, Hulstaert F, Burj J (1987) Distribution and composition of HDL subclasses in students whose parents suffered prematurely from a myocardial infarction in comparison with controls.